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Hilmar PROtelyze™
Bio-Brain

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Smarter Protein For
Brain Health

Hilmar PROtelyze Bio‑Brain is a hydrolyzed whey protein isolate designed to consistently deliver the clinically studied whey peptide GTWY (β‑lactolin) for cognitive support. Developed through controlled enzymatic hydrolysis, it opens a new functional protein space that supports brain health and mobility for healthy‑aging consumers. Human clinical studies demonstrate that a low daily dose supports memory, attention and cognitive performance. With high digestibility, formulation stability and a non‑stimulant profile, PROtelyze Bio‑Brain is ideal for food, beverage and supplement innovations.

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2026 Breakthrough Award Winner

PROtelyze Bio‑Brain is the 2026 recipient of the American Dairy Products Institute and Dairy Foods' Breakthrough Award for Dairy Ingredient Innovation.

Product Info

Cognitive Benefits

  • Enhances memory and learning function
  • Supports cognitive function without stimulation
  • Improves attention and executive function
  •  Provides long-term memory support

Product Features & Benefits

  • High level of bioactive peptides
  • Low daily dose (1g)
  • Lactose-free
  • High digestibility
  • Excellent solubility
  • Heat stable
  • Contains no stimulants

Product Applications

  • RTD beverages & shots
  • RTM beverages & powders
  • Bars
  • Baked goods
  • Yogurt & frozen desserts
  • Gummies
  • Capsules & tablets
Clinical Research Summary – Study Comparison Table Study A: Observed Contexts: Mental fatigue; Primary Outcomes: Verbal fluency, Stroop; Evidence Type: Behavioral testing; Evidence: Shows benefits when cognition is stressed. Study B: Observed Contexts: Age related cognitive effort; Primary Outcomes: Associative memory, attention; Evidence Type: Behavioral testing; Evidence: Shows benefits in age sensitive domains. Study C: Observed Contexts: Working memory under task demand; Primary Outcomes: Prefrontal cerebral blood flow; Evidence Type: Brain level (NIRS / CBF); Evidence: Shows where β Lactolin works in the brain. Study D: Observed Contexts: Attention demanding tasks; Primary Outcomes: Attentional neural activity (P300), verbal fluency; Evidence Type: Brain level (EEG) + behavioral; Evidence: Explains how attention networks are supported.

Human Clinical Evidence

Clinical Research Summary: GTWY (β‑Lactolin)

Clinical support for PROtelyze Bio‑Brain is built on multiple randomized, double‑blind, placebo‑controlled human studies conducted in middle‑aged and older adults. At a daily intake of one gram, GTWY‑rich whey peptides support memory, attention and executive function, with objective EEG and near‑infrared spectroscopy measures demonstrating task‑specific prefrontal activation consistent with improved neural efficiency.

Study Sources

A. Effect of Supplementation of a Whey Peptide Rich in Tryptophan-Tyrosine-Related Peptides on Cognitive Performance in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Kita et al., 2018 Nutrients)

B. Supplementation With Whey Peptide Rich in β-Lactolin Improves Cognitive Performance in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Kita et al., 2019 Frontiers in Neuroscience)

C. β-Lactolin Increases Cerebral Blood Flow in Dorsolateral Prefrontal Cortex in Healthy Adults: A Randomized Controlled Trial (Ano, et al., 2020 Aging/NIRS); Effects of β-Lactolin on Regional Cerebral Blood Flow within the Dorsolateral Prefrontal Cortex during Working Memory Task in Healthy Adults: A Randomized Controlled Trial (Ano et al., 2021 Journal of Clinical Medicine)

D. β-Lactolin Enhances Neural Activity, Indicated by Event-Related P300 Amplitude, in Healthy Adults: A Randomized Controlled Trial (Kanatome et al., 2021 Journal of Alzheimer’s Disease)

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